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PD Dr. sc.nat. André Schmidt PhD

Group leader

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PD Dr. sc. nat. André Schmidt currently works as a Research Group Leader at the University of Basel, Department of Psychiatry (UPK). His research aims to establish reliable biomarkers for clinical services to predict individual disease stages of brain disorders, monitor treatment responses and develop novel interventions.

Projects

Early detection and intervention of psychosis

Microbiome modifications in depression

Selected publications

Wong TY, Radua J, Pomarol-Clotet E, Salvador R, Albajes-Eizagirre A, Solanes A, Canales-Rodriguez EJ, Guerrero-Pedraza A, Sarro S, Kircher T, Nenadic I, Krug A, Grotegerd D, Dannlowski U, Borgwardt S, Riecher-Rössler A, Schmidt A, Andreou C, Huber CG, Turner J, Calhoun V, Jiang W, Clark S, Walton E, Spalletta G, Banaj N, Piras F, Ciullo V, Vecchio D, Lebedeva I, Tomyshev AS, Kaleda V, Klushnik T, Filho GB, Zanetti MV, Serpa MH, Penteado Rosa PG, Hashimoto R, Fukunaga M, Richter A, Krämer B, Gruber O, Voineskos AN, Dickie EW, Tomecek D, Skoch A, Spaniel F, Hoschl C, Bertolino A, Bonvino A, Di Giorgio A, Holleran L, Ciufolini S, Marques TR, Dazzan P, Murray R, Lamsma J, Cahn W, van Haren N, Díaz-Zuluaga AM, Pineda-Zapata JA, Vargas C, López-Jaramillo C, van Erp TGM, Gur RC, Nickl-Jockschat T (2019). An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium. Psychol Med, 16:1-12

Das T, Borgwardt S, Hauke DJ, Harrisberger F, Lang UE, Riecher-Rössler A, Palaniyappan L, Schmidt A (2018). Disorganized Gyrification Network Properties During the Transition to Psychosis. JAMA Psychiatry, 1;75(6):613-622.

Koutsouleris N, Kambeitz-Ilankovic L, Ruhrmann S, Rosen M, Ruef A, Dwyer DB, Paolini M, Chisholm K, Kambeitz J, Haidl T, Schmidt A, Gillam J, Schultze-Lutter F, Falkai P, Reiser M, Riecher-Rössler A, Upthegrove R, Hietala J, Salokangas RKR, Pantelis C, Meisenzahl E, Wood SJ, Beque D, Brambilla P, Borgwardt S; PRONIA Consortium (2018). Prediction Models of Functional Outcomes for Individuals in the Clinical High-Risk State for Psychosis or With Recent-Onset Depression: A Multimodal, Multisite Machine Learning Analysis. JAMA Psychiatry, 1;75(11):1156-1172

Schmidt A, Cappucciati M, Radua J, Rutigliano G, Rocchetti M, Dell’Osso L, Politi P, Borgwardt S, Reilly T, Valmaggia L, McGuire P, Fusar-Poli (2017). Improving prognostic accuracy in subjects at clinical high risk for psychosis: systematic review of predictive models and meta-analytical sequential testing simulation. Schizophrenia Bulletin, 43(2):375-388.

Schmidt A, Crossley NA, Harrisberger F, Smieskova R, Lenz C, Riecher-Rössler A, Lang UE, McGuire P, Fusar-Poli P, Borgwardt S (2016). Structural network disorganization in subjects at clinical high risk for Psychosis. Schizophrenia Bulletin, 43(3):583-591.

Radua J, Schmidt A, Borgwardt S, Heinz A, Schlagenhauf F, Mcguire P, Fusar-Poli P (2015). Ventral striatal activation during reward processing in psychosis: A neurofunctional meta-analysis. JAMA Psychiatry, 72(12):1243-1251.

Schmidt A, Walter M, Gerber H, Seifritz E, Brenneisen R, Wiesbeck G, Riecher-Rössler A, Lang UE, Borgwardt S (2015). Normalising effect of heroin maintenance treatment on stress-induced brain connectivity. Brain, 138(Pt 1):217-228.

Schmidt A, Borgwardt S, Gerber H, Wiesbeck G, Schmid O, Riecher-Rössler A, Smieskova R, Lang UE, Walter M (2014). Acute effects of heroin on negative emotional processing: relation of amygdala activity and stress-related responses. Biological Psychiatry, 76(4):289-296.

Schmidt, A, Smieskova R, Aston, J, Simon A, Allen P, Fusar-Poli P, McGuire PK, Riecher-Rössler A, Stephan KE, Borgwardt S (2013). Brain connectivity abnormalities predating the onset of psychosis: correlation with the effect of medication. JAMA Psychiatry, 70(9):903-912.

Kometer M, Schmidt A, Jäncke L, Vollenweider FX (2013). Activation of serotonin 2A receptors underlies the psilocybin-induced effects on α oscillations, N170 visual-evoked potentials, and visual hallucinations. Journal of Neuroscience, 33(25):10544-10551.

Schmidt A, Diaconescu AO, Kometer M, Friston KJ, Stephan KE, Seifritz E, Vollenweider FX (2013). Modeling Ketamine Effects on Synaptic Plasticity During the Mismatch Negativity. Cerebral Cortex, 23(10):2394-2406.

Kometer M, Schmidt A, Bachmann R, Vollenweider FX (2012). Psilocybin biases facial recognition, goal-directed behavior, and mood state towards positive relative to negative emotions through different serotonergic subreceptors. Biological Psychiatry, 72(11):898-906.

Schmidt A, Bachmann R, Kometer M, Csomor PA, Stephan KE, Seifritz E, Vollenweider FX (2012). Mismatch negativity encoding of prediction errors predicts S-ketamine-induced cognitive impairments. Neuropsychopharmacology 37:865-75.

Schmidt A, Kometer M, Bachmann R, Seifritz E, Vollenweider FX (2012). The NMDA antagonist ketamine and the 5-HT agonist psilocybin produce dissociable effects on structural encoding of emotional face expressions. Psychopharmacology 2013 Jan;225(1):227-39. doi: 10.1007/s00213-012-2811-0. Epub 2012 Jul 27.

Borgwardt S, Schmidt A (2012). Molecular Bases Of Antipsychotic Drugs: The Contribution Of Neurosciences. Curr Med Chem 2013;20(3):311. Smieskova R, Marmy J, Schmidt A, Bendfeldt K, Riecher-Rössler A, Walter M, Lang UE, Borgwardt S (2012). Do subjects at clinical high risk for psychosis differ from those with a genetic high risk? – A systematic review of structural and functional brain abnormalities. Curr Med Chem, 2013;20(3):467-81.

Prizes, Awards, Fellowships'

Research Fund outstanding junior researchers, University of Basel

Forschungsförderungsfonds, University Hospital of Psychiatry Basel

Frutiger Research Award

Travel Fellowship for the 6th Schizophrenia International Research Society (SIRS) Conference

Young Investigator Award, Swiss Society of Biological Psychiatry (SSBP)

Aretaeus Schizophrenia Award, European Scientific Association on Schizophrenia and other Psychoses (ESAS)

Young Investigator Award, Electroencephalography and Clinical Neuroscience Society (ECNS)

Young Investigator Award, World Federation of Societies of Biological Psychiatry (WFSBP)

Travel Fellowship for the 5th Schizophrenia International Research Society (SIRS) Conference

Swiss Addiction Research Award, Swiss Society of Addiction Medicine (SSAM)

Postdoc Mobility Fellowship, Swiss National Science Foundation (SNSF)

Research Excellence Fellowship, Institute of Psychiatry, Psychology and Neuroscience, King’s College London

Travel Fellowship for the 26th European College of Neuropsychopharmacology (ECNP) Conference

Best Publication Award 2011, Faculty of Medicine, University of Zurich

Travel Fellowship for the 24th European College of Neuropsychopharmacology (ECNP) Conference