Pathophysiological mechanisms of persecutory delusions
Identifying robust markers for predicting the onset of psychosis has been a key challenge for early detection research. Persecutory delusions are core symptoms of psychosis, and social cognition is particularly impaired in first-episode psychosis patients and individuals at risk for developing psychosis. In this project, we introduce new avenues for translation provided by hierarchical Bayesian models of behavior and neuroimaging data applied in the context of social learning to target persecutory delusions. These generative models are aimed to identify the pathophysiological mechanisms related to the emergence of persecutory delusions placing individuals at risk for psychosis.