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Brain-gut interactions

Microbiome modifications in depression

Alterations in the composition of the gut microbiota influence brain function and behavior via the brain-gut axis. Elucidating the pathways linking gut-microbiota and the brain may allow detecting potential biomarkers that could be used in psychiatry. There is a particular need in major depressive disorder (MDD) to identify biomarkers that can stratify patients into more homogeneous groups to achieve better treatment outcomes since up to 40% do not respond to current treatment approaches. In the brain-gut project, we are also investigating the effects of two microbiota-directed interventions, namely probiotic augmentation and intestinal microbiota transplantation on immunological, inflammatory, microbial, genetic and neural markers along the brain-gut axis in patients with MDD. The findings reached may serve as basis for further developments of novel microbial interventions for these patients.


PEOPLE

Andre

PD Dr. sc.nat. André Schmidt PhD

Group leader

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CONTACT

PD Dr. André Schmidt PhD

Department of Psychiatry (UPK) Basel

Wilhelm Klein Strasse 27
4012 Basel
Switzerland

e-mail: andre.schmidt@upk.ch

gy

Dr. rer.nat. Gulnara Yamanbaeva PhD

Post doc

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jr

Jessica Roth

PhD student

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anna

Anna-Chiara Schaub MSc

PhD student

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