The research carried out by the research group is mainly focused on the aetiology and pathophysiological mechanisms underlying the development of psychosis, and on the development of new treatments for psychotic disorders. Research studies involve people with subclinical symptoms, groups at high risk for psychosis, and patients with psychotic symptoms. Research activity is directly integrated with the clinical services in the Psychiatric University Hospital, UPK Basel and with Departments of the University Hospital Basel. This fusion of the research and clinical infrastructure ensures that research and teaching reflect current clinical priorities, and that clinical practice is informed by the latest research findings.

We use a wide range of research methods, including advanced neuroimaging techniques (structural and functional MRI, DTI), dynamic causal modeling (DCM), multimodal imaging, pharmacological imaging, imaging genetics as well as psychopathological and cognitive assessments in clinical populations and healthy volunteers. Facilities for image acquisition and analysis are provided by the University Hospital Basel and the Medical Image Analysis Centre.

 

Funded Research Projects

 

EU FP7 Project: Personalised Prognostic Tools for Early Psychosis Management

http://www.pronia.eu/

http://ec.europa.eu/research/health/medical-research/brain-research/projects/pronia_en.html

 

Brain – gut interaction: Defining the role of carbohydrate in the nutrient‐induced human brain activation matrix

http://p3.snf.ch/Project-138157

 

Brain structural and neurofunctional correlates of liability to psychosis

http://p3.snf.ch/Project-119382

 

European Union EU-FP7 study “European Network of National Schizophrenia Networks Studying Gene-Environment Interactions“

http://www.eu-gei.eu/

 

The effects of diacetylmorphine (heroin) on human brain function and stress response

http://p3.snf.ch/Project-127544

 

Vulnerability and resilience factors of schizophrenia: An approach combining neuroimaging, neuropsychological and neurobiological methods

http://p3.snf.ch/Project-127323

 

Association of progressive white matter lesions and gray matter atophy in patients with multiple sclerosis