RESEARCH PROFILEBASIC NEUROSCIENCE: cell culture, molecular biological and biochemical techniques
ELECTROPHYSIOLOGY: short circuit current (Ussing), conductance scanning, patch clamp, transmural impedance, laser doppler
HISTOLOGY: immunohistochemistry, electron microscopy, confocal microscopy
FUNCTIONAL NEUROANATOMY: animal operation (forebrain ischemia, stereotaxic techniques, BCCAO)
CLINICAL NEUROSCIENCE, NEUROIMAGING: multimodal imaging (FSL, SPM, VBM, SVM), multiple sclerosis, atrophy, neurodegeneration, inflammation, blood-brain barrier disturbances, prediction of disease evolution and therapy response
BACKGROUNDDr. rer. nat. Kerstin Bendfeldt 1997-2000 studied biology at the Free University of Berlin. She completed her Ph.D. (DFG-Graduiertenkolleg 276/1; granted by the German Reseach Foundation) at the Institute of Clinical Physiology, Charité, University Medicine Berlin and the Institute of Neurobiology, FU Berlin, performing electrophysiological studies on tissue models of epithelial barrier function related to diseases of the intestine. From 2001-2006 she worked as a post-doc at the Institute of Anatomy, University of Basel, Dept. of Neuroanatomy focusing on the ‚role of calcium binding proteins in the special vulnerability of regional brain areas towards ischemia‘ and the implementation of in-vitro models of the blood-brain barrier to study barrier function under neuropathological conditions. Since 2007 she works at the Medical Image Analysis Center (MIAC), University Hospital Basel; 03/2012: postdoctoral lecture qualification, Medical Faculty, University of Basel; main research topic: ‚in-vivo imaging of gray and white matter abnormalities in MS‘.
CURRENT RESEARCH PROJECTSSpatiotemporal distribution patterns of white matter lesions and regional grey matter abnormalities in different stages of MS.
Predicting disease evolution and treatment response in MS using multimodal imaging and support vector machines.
Spatiotemporal distribution of white matter lesions in relapsing-remitting and secondary progressive multiple sclerosis.
Filli L, Hofstetter L, Kuster P, Traud S, Mueller-Lenke N, Naegelin Y, Kappos L, Gass A, Sprenger T, Nichols TE, Vrenken H, Barkhof F, Polman C, Radue EW, Borgwardt SJ, Bendfeldt K. Mult Scler. 2012 Apr 11. IF 4.255
Multivariate pattern classification of gray matter pathology in multiple sclerosis.
Bendfeldt K, Klöppel S, Nichols TE, Smieskova R, Kuster P, Traud S, Mueller-Lenke N, Naegelin Y, Kappos L, Radue EW, Borgwardt SJ. Neuroimage 2012 Mar; 60(1):400-8. IF 6.256